Visualization of G1 chromosomes: a folded, twisted, supercoiled chromonema model of interphase chromatid structure

@article{Belmont1994VisualizationOG,
  title={Visualization of G1 chromosomes: a folded, twisted, supercoiled chromonema model of interphase chromatid structure},
  author={Andrew S Belmont and Kimberley Bruce},
  journal={The Journal of Cell Biology},
  year={1994},
  volume={127},
  pages={287 - 302}
}
We have used light microscopy and serial thin-section electron microscopy to visualize intermediates of chromosome decondensation during G1 progression in synchronized CHO cells. In early G1, tightly coiled 100-130-nm "chromonema" fibers are visualized within partially decondensed chromatin masses. Progression from early to middle G1 is accompanied by a progressive uncoiling and straightening of these chromonema fibers. Further decondensation in later G1 and early S phase results in… CONTINUE READING

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A three-dimensional approach to mitotic chromosome structure: evidence for a complex hierarchical organization

  • A. S. Belmont, J. W. Sexlat, D. A. Agard.
  • J. Cell Biol. 105:77-92.
  • 1987
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