Visualization of DNA G-quadruplexes in herpes simplex virus 1-infected cells

  title={Visualization of DNA G-quadruplexes in herpes simplex virus 1-infected cells},
  author={Sara Artusi and R Perrone and Sara Lago and Paolo Raffa and Enzo Di Iorio and Giorgio Pal{\`u} and Sara N Richter},
  booktitle={Nucleic acids research},
We have previously shown that clusters of guanine quadruplex (G4) structures can form in the human herpes simplex-1 (HSV-1) genome. Here we used immunofluorescence and immune-electron microscopy with a G4-specific monoclonal antibody to visualize G4 structures in HSV-1 infected cells. We found that G4 formation and localization within the cells was virus cycle dependent: viral G4s peaked at the time of viral DNA replication in the cell nucleus, moved to the nuclear membrane at the time of virus… CONTINUE READING
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