Visualization of CD146 dimerization and its regulation in living cells.

  title={Visualization of CD146 dimerization and its regulation in living cells.},
  author={Pengcheng Bu and Jie Zhuang and Jing Feng and Dongling Yang and Xun Shen and Xiyun Yan},
  journal={Biochimica et biophysica acta},
  volume={1773 4},
Our previous study showed that the adhesion molecule CD146 as a biomarker is over-expressed on activated endothelium during angiogenesis, which was induced by tumor conditional medium and inhibited by anti-CD146 monoclonal antibody (mAb AA98). However, the CD146 molecular organization on the cells is unknown. Here, using immunoprecipitation, we found that the dimerization of CD146 occurs in both normal and tumor cells. However, the dimer/monomer ratio was higher in tumor cells than in normal… CONTINUE READING
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