Visualization, quantification and correlation of brain atrophy with clinical symptoms in spinocerebellar ataxia types 1, 3 and 6

Abstract

BACKGROUND AND OBJECTIVE Biomarkers to monitor neurological dysfunction in autosomal dominant inherited spinocerebellar ataxias (SCA) are lacking. We therefore aimed to visualize, quantify and correlate localized brain atrophy with clinical symptoms in SCA1, SCA3, and SCA6. METHODS We compared patients suffering from SCA1 (n=48), SCA3 (n=24), and SCA6 (n… (More)
DOI: 10.1016/j.neuroimage.2009.07.027

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