Visual transmission deficits in mice with targeted disruption of the gap junction gene connexin36.

@article{Gueldenagel2001VisualTD,
  title={Visual transmission deficits in mice with targeted disruption of the gap junction gene connexin36.},
  author={Martin Gueldenagel and Josef Ammerm{\"u}ller and Andreas Feigenspan and Barbara Teubner and Joachim Degen and Goran S{\"o}hl and Klaus Willecke and Reto Weiler},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2001},
  volume={21 16},
  pages={6036-44}
}
In the mammalian retina, rods feed into the cone pathway through electrotonic coupling, and recent histological data suggest the involvement of connexin36 (Cx36) in this pathway. We therefore generated Cx36 null mice and monitored the functional consequences of this deficiency on early visual transmission. The homozygous mutant mice had a normally developed retina and showed no changes in the cellular organization of the rod pathway. In contrast, the functional coupling between AII amacrine… CONTINUE READING
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