Visual transduction in Drosophila

@article{Hardie2001VisualTI,
  title={Visual transduction in Drosophila},
  author={Roger C. Hardie and Padinjat Raghu},
  journal={Nature},
  year={2001},
  volume={413},
  pages={186-193}
}
The brain's capacity to analyse and interpret information is limited ultimately by the input it receives. This sets a premium on information capacity of sensory receptors, which can be maximized by optimizing sensitivity, speed and reliability of response. Nowhere is selection pressure for information capacity stronger than in the visual system, where speed and sensitivity can mean the difference between life and death. Phototransduction in flies represents the fastest G-protein-signalling… 

Noise reduction in analogue computation of Drosophila photoreceptors

TLDR
How a relatively simple invertebrate organism suppresses noise at the molecular level, to the extent that it is able to detect a single photon at room temperatures, might be an inspiration in reaching the physical limits of information processing.

Fly visual course control: behaviour, algorithms and circuits

  • A. Borst
  • Biology
    Nature Reviews Neuroscience
  • 2014
TLDR
By focusing on fly visual course control, this work highlights what has been learned about the neuronal circuit modules that control visual guidance in Drosophila melanogaster through the use of genetic and recording techniques.

Modelling and analysis of Drosophila early visual system : a systems engineering approach

TLDR
This thesis derives and analyzes the rate-distortion characteristics associated with the linear and nonlinear transformations performed by photoreceptors on a stimulus generated by a signal source with a well defined distribution and suggests that this processing strategy achieves an optimal trade-off between the two competing goals of minimizing distortion in decoding behaviourally relevant stimuli features and minimizing the information rate.

Investigating through multiple experimental approaches how early visual circuit functions affect Drosophila behaviour

TLDR
The flight simulator is used to show that the absence of ‘chromatic’ photoreceptors adversely affects visually-driven optomotor behaviour, and that Ca2+-activated K+ channel mutations in post-synaptic Large Monopolar Cells can affect visual behaviour, but that these effects are often managed by homeostatic mechanisms that serve to maintain biologically-relevant function.

Visual Coding in Locust Photoreceptors

TLDR
It is found that brightening or warming increase and accelerate voltage responses, but reduce noise, enabling photoreceptors to encode more information, and suggests that biochemical constraints imposed upon signaling change continuously as locust photoresceptors adapt to environmental light and temperature conditions.

Retrograde signaling from the brain to the retina modulates the termination of the light response in Drosophila.

TLDR
It is found that prompt restoration to the resting state of the Drosophila electroretinogram can require effective communication between the retina and the underlying brain, and infer that signaling from the retina to the optic lobe prompts a feedback signal to retinal PRs.

A Parallel Processing Model of the Drosophila Retina

TLDR
A detailed description of the algorithms required for a full-scale parallel emulation of the Retina including (i) the mapping of the visual field onto the photoreceptors, (ii) the phototransduction process, and (iii) the parallel processing of theVisual field by the entire Retina are presented.

Network Adaptation Improves Temporal Representation of Naturalistic Stimuli in Drosophila Eye: I Dynamics

TLDR
By analyzing the continuous photoreceptor-to-LMC transformations of these graded-potential neurons, it is shown that the efficiency of coding is dynamically improved by adaptation, and that these coding properties can be used to study network adaptation using the genetic tools in Drosophila.
...

References

SHOWING 1-10 OF 93 REFERENCES

Visual transduction in Drosophila.

  • C. Montell
  • Biology
    Annual review of cell and developmental biology
  • 1999
TLDR
It has become apparent that most of the proteins central to Drosophila phototransduction are coupled into a supramolecular signaling complex, signalplex, through association with a PDZ-containing scaffold protein.

Regulation of sensitivity in vertebrate rod photoreceptors by calcium

The metabolic cost of neural information

TLDR
Biophysical measurements from cells in the blowfly retina yield estimates of the energy required to generate graded (analog) electrical signals that transmit known amounts of information, which promotes the distribution of information among multiple pathways.

TRP trapped in fly signaling web

  • C. Montell
  • Biology
    Current Opinion in Neurobiology
  • 1998

Light Adaptation in Drosophila Photoreceptors: I. Response Dynamics and Signaling Efficiency at 25°C

TLDR
This work investigated the response dynamics and signaling efficiency of Drosophila photoreceptors to natural-like fluctu- ating light contrast stimulation and intracellular current injection when the cells were adapted over a 4-log unit light intensity range at 25 8 C.

Membrane protein diffusion sets the speed of rod phototransduction

TLDR
It is shown that a roughly 50% reduction in protein crowding achieved by the hemizygous knockout of rhodopsin in transgenic mice accelerates the rising phases and recoveries of flash responses by about 1.7-fold in vivo.

The photoreceptor array of the dipteran retina

Assembly of the Drosophila phototransduction cascade into a signalling complex shapes elementary responses

TLDR
This work studies single-photon responses in several photoreceptor mutant backgrounds, and shows that the InaD macromolecular complex is the unit of signalling that underlies elementary responses and that the localized activity of this signalling unit promotes reliable single-Photon responses as well as rapid activation and feedback regulation.

Lights out: deactivation of the phototransduction cascade.

...