Visual recovery in a man with the rare combination of mtDNA 11778 LHON mutation and a MS-like disease after mitoxantrone therapy.

@article{Buhmann2002VisualRI,
  title={Visual recovery in a man with the rare combination of mtDNA 11778 LHON mutation and a MS-like disease after mitoxantrone therapy.},
  author={Carsten Buhmann and Joystone Gbadamosi and Christoph Heesen},
  journal={Acta neurologica Scandinavica},
  year={2002},
  volume={106 4},
  pages={236-9}
}
We describe a young man with prognostic unfavourable homoplasmatic mitochondrial DNA(mt DNA) 11778 Leber's hereditary optic neuropathy (LHON) point mutation and confirmed multiple sclerosis (MS). This combination of LHON and MS-like disease is rare in both sexes, and in men has been described in only a few case reports. In a 4-year follow-up during… CONTINUE READING