Visual evoked responses as a monitor of intracranial pressure during hyperosmolar blood-brain barrier disruption.

Abstract

Intracarotid mannitol (HBBBD = hyperosmotic BBB disruption) as a method of transiently increasing solute/drug delivery to brain parenchyma has been associated in animals with a 1-2% increase in brain water and an increase in cisternal ICP. To determine whether these changes are clinically significant, we investigated ICP changes associated with HBBBD in 33… (More)

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