Visual-discrimination learning ability and beta-amyloid accumulation in the dog.

  title={Visual-discrimination learning ability and beta-amyloid accumulation in the dog.},
  author={Elizabeth Head and Heather Callahan and Bruce A. Muggenburg and Carl Cotman and Norton William Milgram},
  journal={Neurobiology of aging},
  volume={19 5},
Young, middle-aged, and old beagle dogs were tested on several visual-discrimination tasks: reward- and object-approach learning, object discrimination and reversal, long-term retention of a reversal problem, and a size-discrimination task. Beta-amyloid accumulation in the entorhinal, prefrontal, parietal, and occipital cortices was quantified using immunohistochemical and imaging techniques at the conclusion of cognitive testing. Middle-aged and old dogs were impaired in size-discrimination… CONTINUE READING