Visual detection of microRNA with lateral flow nucleic acid biosensor.

  title={Visual detection of microRNA with lateral flow nucleic acid biosensor.},
  author={Xuefei Gao and Hui Xu and Meenu Baloda and Anant S Gurung and Li-ping Xu and Tao Wang and Xueji Zhang and Guodong Liu},
  journal={Biosensors & bioelectronics},
We report a DNA-gold nanoparticle (DNA-GNP) based lateral flow nucleic acid biosensor for visual detection of microRNA (miRNA)-215 in aqueous solutions and biological samples with low-cost and short analysis time. Sandwich-type hybridization reactions among GNP-labeled DNA probe, miRNA-215 and biotin-modified DNA probes were performed on the lateral flow device. The accumulation of GNPs on the test zone of the biosensor enables the visual detection of miRNA-215. After systematic optimization… CONTINUE READING
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