Visual Sensorial Impairments in Neurodevelopmental Disorders: Evidence for a Retinal Phenotype in Fragile X Syndrome

@inproceedings{Rossignol2014VisualSI,
  title={Visual Sensorial Impairments in Neurodevelopmental Disorders: Evidence for a Retinal Phenotype in Fragile X Syndrome},
  author={Rafa{\"e}lle Rossignol and Isabelle Ranchon-Cole and Arnaud Paris and Am{\'e}ziane Herzine and Astrid Perche and David Laurenceau and Pauline Coti Bertrand and Christine Cercy and Jacques L. Pichon and St{\'e}phane Mortaud and Sylvain Briault and Arnaud Menuet and Olivier Perche},
  booktitle={PloS one},
  year={2014}
}
Visual sensory impairments are common in Mental Deficiency (MD) and Autism Spectrum Disorder (ASD). These defects are linked to cerebral dysfunction in the visual cortical area characterized by the deregulation of axon growth/guidance and dendrite spine immaturity of neurons. However, visual perception had not been addressed, although the retina is part of the central nervous system with a common embryonic origin. Therefore, we investigated retinal perception, the first event of vision, in a… CONTINUE READING

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Mentioned Connections BETA
AxonSibling in is aDendrites
These defects are linked to cerebral dysfunction in the visual cortical area characterized by the deregulation of axon growth / guidance and dendrite spine immaturity of neurons .
DendritesSibling in is aAxon
These defects are linked to cerebral dysfunction in the visual cortical area characterized by the deregulation of axon growth / guidance and dendrite spine immaturity of neurons .
AxonNo subtypeDendrites
These defects are linked to cerebral dysfunction in the visual cortical area characterized by the deregulation of axon growth / guidance and dendrite spine immaturity of neurons .
DendritesNo subtypeAxon
These defects are linked to cerebral dysfunction in the visual cortical area characterized by the deregulation of axon growth / guidance and dendrite spine immaturity of neurons .
In addition , we observed an alteration of the visual signal transmission between photoreceptors and the inner retina which could be attributed to deregulations of pre- and post- synaptic proteins resulting in retinal neurons synaptic destabilization and to retinal neurons immaturity .
In addition , we observed an alteration of the visual signal transmission between photoreceptors and the inner retina which could be attributed to deregulations of pre- and post- synaptic proteins resulting in retinal neurons synaptic destabilization and to retinal neurons immaturity .
In addition , we observed an alteration of the visual signal transmission between photoreceptors and the inner retina which could be attributed to deregulations of pre- and post- synaptic proteins resulting in retinal neurons synaptic destabilization and to retinal neurons immaturity .
In addition , we observed an alteration of the visual signal transmission between photoreceptors and the inner retina which could be attributed to deregulations of pre- and post- synaptic proteins resulting in retinal neurons synaptic destabilization and to retinal neurons immaturity .
In addition , we observed an alteration of the visual signal transmission between photoreceptors and the inner retina which could be attributed to deregulations of pre- and post- synaptic proteins resulting in retinal neurons synaptic destabilization and to retinal neurons immaturity .
Indeed , In Fmr1 KO mice had a lower retinal function characterized by a decreased photoreceptors neuron response , due to a 40% decrease in Rhodopsin content and to Rod Outer Segment destabilization .
Thus , for the first time , we demonstrated that retinal perception is altered in a murine model of MD with autistic features and that there are strong similarities between cerebral and retinal cellular and molecular defects .
Thus , for the first time , we demonstrated that retinal perception is altered in a murine model of MD with autistic features and that there are strong similarities between cerebral and retinal cellular and molecular defects .
RetinaIs associated anatomic site ofRetinal Diseases
Thus , for the first time , we demonstrated that retinal perception is altered in a murine model of MD with autistic features and that there are strong similarities between cerebral and retinal cellular and molecular defects .
Thus , for the first time , we demonstrated that retinal perception is altered in a murine model of MD with autistic features and that there are strong similarities between cerebral and retinal cellular and molecular defects .
In addition , we observed an alteration of the visual signal transmission between photoreceptors and the inner retina which could be attributed to deregulations of pre- and post- synaptic proteins resulting in retinal neurons synaptic destabilization and to retinal neurons immaturity .
In addition , we observed an alteration of the visual signal transmission between photoreceptors and the inner retina which could be attributed to deregulations of pre- and post- synaptic proteins resulting in retinal neurons synaptic destabilization and to retinal neurons immaturity .
In addition , we observed an alteration of the visual signal transmission between photoreceptors and the inner retina which could be attributed to deregulations of pre- and post- synaptic proteins resulting in retinal neurons synaptic destabilization and to retinal neurons immaturity .
In addition , we observed an alteration of the visual signal transmission between photoreceptors and the inner retina which could be attributed to deregulations of pre- and post- synaptic proteins resulting in retinal neurons synaptic destabilization and to retinal neurons immaturity .
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