Visual Evidence of Acidic Environment Within Degrading Poly(lactic-co-glycolic acid) (PLGA) Microspheres

@article{Fu2000VisualEO,
  title={Visual Evidence of Acidic Environment Within Degrading Poly(lactic-co-glycolic acid) (PLGA) Microspheres},
  author={Karen J Fu and Daniel W Pack and Alexander M. Klibanov and Robert Langer},
  journal={Pharmaceutical Research},
  year={2000},
  volume={17},
  pages={100-106}
}
Purpose. In the past decade, biodegradable polymers have becomethe materials of choice for a variety of biomaterials applications. Inparticular, poly(lactic-co-glycolic acid) (PLGA) microspheres havebeen extensively studied for controlled-release drug delivery. However,degradation of the polymer generates acidic monomers, andacidification of the inner polymer environment is a central issue in thedevelopment of these devices for drug delivery. Methods. To quantitatively determine the… CONTINUE READING
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