Visual Deprivation Suppresses L5 Pyramidal Neuron Excitability by Preventing the Induction of Intrinsic Plasticity

@article{Nataraj2010VisualDS,
  title={Visual Deprivation Suppresses L5 Pyramidal Neuron Excitability by Preventing the Induction of Intrinsic Plasticity},
  author={Kiran Nataraj and Nicolas Le Roux and Marc Nahmani and Sandrine Lefort and Gina G. Turrigiano},
  journal={Neuron},
  year={2010},
  volume={68},
  pages={750-762}
}
In visual cortex monocular deprivation (MD) during a critical period (CP) reduces the ability of the deprived eye to activate cortex, but the underlying cellular plasticity mechanisms are incompletely understood. Here we show that MD reduces the intrinsic excitability of layer 5 (L5) pyramidal neurons and enhances long-term potentiation of intrinsic excitability (LTP-IE). Further, MD and LTP-IE induce reciprocal changes in K(v)2.1 current, and LTP-IE reverses the effects of MD on intrinsic… CONTINUE READING