Visual Circuit Development Requires Patterned Activity Mediated by Retinal Acetylcholine Receptors

@article{Burbridge2014VisualCD,
  title={Visual Circuit Development Requires Patterned Activity Mediated by Retinal Acetylcholine Receptors},
  author={Timothy J. Burbridge and Hong-ping Xu and James B Ackman and Xinxin Ge and Yueyi Zhang and Mei-Jun Ye and Z. Jimmy Zhou and Jian Xu and Anis Contractor and Michael C. Crair},
  journal={Neuron},
  year={2014},
  volume={84},
  pages={1049-1064}
}
The elaboration of nascent synaptic connections into highly ordered neural circuits is an integral feature of the developing vertebrate nervous system. In sensory systems, patterned spontaneous activity before the onset of sensation is thought to influence this process, but this conclusion remains controversial, largely due to the inherent difficulty recording neural activity in early development. Here, we describe genetic and pharmacological manipulations of spontaneous retinal activity… CONTINUE READING