Visoltricin, a novel biologically active compound produced by Fusarium tricinctum.

  title={Visoltricin, a novel biologically active compound produced by Fusarium tricinctum.},
  author={A. Visconti and M. Solfrizzo},
  journal={Food additives and contaminants},
  volume={12 3},
The major compound responsible for toxicity to Artemia salina of some Fusarium tricinctum strains has been isolated, and its structure has been elucidated by spectroscopical methods, i.e. UV, IR, MS, 1H-NMR and 13C-NMR. The novel compound, trivially named visoltricin, is the first imidazole derivative produced by Fusarium spp., and its structure has been established as the methyl ester of 3-[1-methyl-4-(3-methyl-2-butenyl)-imidazol-5yl]-2-propenoic acid (molecular formula C13H18N2O2; MW = 234… Expand
Synthesis of visoltricin and fungerin: imidazole derivatives of Fusarium sp.
The synthesis of two imidazole derivatives of Fusarium sp. is described. 3-[1-Methyl-4-(3-methyl-2-butenyl)-1H-imidazol-5-yl]-2(E)-propenoic acid methylester was synthesized for the first time andExpand
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All Fusarium species studied showed significant cytotoxicity, but with a large variation between species, and also within each species, including F. equiseti, which showed the highest average cytot toxicity. Expand
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183 compounds obtained from plants and fungi which have been shown to inhibit acetylcholinesterase are described, mainly alkaloids although some meroterpenoids from fungi have also been found to be active and display better selectivity. Expand
Fungerin, a fungal alkaloid, arrests the cell cycle in M phase by inhibition of microtubule polymerization.
It was concluded that fungerin arrests the cell cycle at the M phase through inhibition of microtubule polymerization. Expand
Direct Assembly of Prenylated Heteroarenes through a Cascade Minisci Reaction/Dehydration Sequence
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Étude de deux maladies chez la carotte porte-graine causées par les espèces fongiques Fusarium tricinctum et Diaporthe angelicae
Il a ete mis en evidence that D. angelicae serait un pathogene vasculaire, a permis de montrer qu’une penetration du pathogene par les stomates a la base des styles de l’hote existe, mais de mettre en avant les proprietes de parasitisme d’un souche marine de Trichoderma issue du laboratoire MMS de Nantes. Expand


Isolation, characterization and biological activity of visoltricin, a novel metabolite of Fusarium tricinctum
It is confirmed that F. tricinctum from various substrates and geographic areas produced visoltricin when grown on corn, and it is the first imidazole derivative produced by a Fusarium species. Expand
Anticholinesterase activity of the fusarium metabolite visoltricin and its N-methyl derivative.
  • M. Solfrizzo, A. Visconti
  • Chemistry, Medicine
  • Toxicology in vitro : an international journal published in association with BIBRA
  • 1994
Visoltricin was a reversible inhibitor of acetylcholinesterase, as it was not hydrolysed by the inhibited enzyme, and the inhibition in vitro was concentration dependent but not time dependent. Expand
Further data on specific trichothecene production by Fusarium sect. Sporotrichiella strains.
Thirty-seven Fusarium strains belonging to different species of the Sporotrichiella section, from different plant and geographic origins, were tested for production of trichothecene derivatives on autoclaved com kernels, finding that two strains of F. tricinctum and F. chlamydosporum showed toxicity related to unidentified compounds. Expand
Mycotoxins produced by Fusarium acuminatum. Isolation and characterization of acuminatin: a new trichothecene
Culture extracts of eight strains F. acuminatum isolated in Italy from soil and corn stalk or ear contained considerable amounts of trichothecenes, were highly toxic to Artemia salina larvae, andExpand
Miotic activity produced by inhibitors of acetylcholinesterase.
The 3-picoline derivative is a very toxic agent in mice, however it is equal to 2-pic Caroline in activity as an inhibitor of acetylcholinesterase. Expand
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Evaluation of kinetic constants for mixed inhibitors of cholinesterase.
For two compounds, trimethylamine and psilocin, it was observed that K I ′ K I was observed, which demonstrates that inhibitor is bound more tightly to an enzyme-substrate complex than to free enzyme, and is used as evidence for the “induced fit” theory of enzyme structure. Expand
A new and rapid colorimetric determination of acetylcholinesterase activity.
A photometric method for determining acetylcholinesterase activity of tissue extracts, homogenates, cell suspensions, etc., has been described and Kinetic constants determined by this system for erythrocyte eholinesterases are presented. Expand