Vismodegib and the hedgehog pathway: a new treatment for basal cell carcinoma.

@article{Cirrone2012VismodegibAT,
  title={Vismodegib and the hedgehog pathway: a new treatment for basal cell carcinoma.},
  author={Frank Cirrone and Christy S Harris},
  journal={Clinical therapeutics},
  year={2012},
  volume={34 10},
  pages={
          2039-50
        }
}
BACKGROUND Vismodegib is an oral inhibitor of the Hedgehog pathway approved by the US Food and Drug Administration. It is the first systemic treatment for patients with locally advanced or metastatic basal cell carcinoma that is not amenable to surgery and radiation. This is the first drug to use the Hedgehog pathway to inhibit the proliferation of tumors and is also implicated in the development of other cancers such as medulloblastoma. OBJECTIVE The goal of this review was to summarize the… CONTINUE READING
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