Visible spectrophotometric and first-derivative UV spectrophotometric determination of rifampicin and isoniazid in pharmaceutical preparations.

@article{Benetton1998VisibleSA,
  title={Visible spectrophotometric and first-derivative UV spectrophotometric determination of rifampicin and isoniazid in pharmaceutical preparations.},
  author={S A Benetton and Erika Rosa Maria Kedor-Hackmann and M I Santoro and Val{\'e}ria Matos Borges},
  journal={Talanta},
  year={1998},
  volume={47 3},
  pages={
          639-43
        }
}
Two methods are described for the determination of rifampicin and isoniazid in mixtures by visible spectrophotometry and first-derivative ultraviolet spectrophotometry. The absorbance at 475 nm in buffer solution pH 7.4 was employed to determine rifampicin after applying the three-point correction technique between 420 and 520 nm, while the amplitude of the first-derivative spectrophotometric spectrum at 257 nm in HCl 0.012 M was selected for the determination of isoniazid. The methods are… CONTINUE READING

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