Visible light-induced crosslinking and physiological stabilization of diselenide-rich nanoparticles for redox-responsive drug release and combination chemotherapy.

@article{Zhai2017VisibleLC,
  title={Visible light-induced crosslinking and physiological stabilization of diselenide-rich nanoparticles for redox-responsive drug release and combination chemotherapy.},
  author={Shaodong Zhai and Xianglong Hu and Yongjun Hu and Baoyan Wu and Da Xing},
  journal={Biomaterials},
  year={2017},
  volume={121},
  pages={41-54}
}
Undesired physiological instability of nanocarriers and premature drug leakage during blood circulation result in compromised therapeutic efficacy and severe side effects, which have significantly impeded the development of nanomedicine. Facile crosslinking of drug-loaded nanocarriers while keeping the potency of site-specific degradation and drug release has emerged as a viable strategy to overcome these drawbacks. Additionally, combination therapy has already shown advantages in inhibiting… CONTINUE READING
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