Visible-Light-Driven Palladium-Catalyzed Radical Alkylation of C-H Bonds with Unactivated Alkyl Bromides.

Abstract

Reported herein is a novel visible-light photoredox system with Pd(PPh3 )4 as the sole catalyst for the realization of the first direct cross-coupling of C(sp3 )-H bonds in N-aryl tetrahydroisoquinolines with unactivated alkyl bromides. Moreover, intra- and intermolecular alkylations of heteroarenes were also developed under mild reaction conditions. A… (More)
DOI: 10.1002/anie.201704513

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@article{Zhou2017VisibleLightDrivenPR, title={Visible-Light-Driven Palladium-Catalyzed Radical Alkylation of C-H Bonds with Unactivated Alkyl Bromides.}, author={Wen-Jun Zhou and Guang-Mei Cao and Guo Shen and Xing-Yong Zhu and Yong-Yuan Gui and Jian-Heng Ye and Liang Sun and Li-Li Liao and Jing Li and Da-Gang Yu}, journal={Angewandte Chemie}, year={2017}, volume={56 49}, pages={15683-15687} }