Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin

@article{Fukuhara2005VisfatinAP,
  title={Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin},
  author={Atsunori Fukuhara and Morihiro Matsuda and Masako Nishizawa and Katsumori Segawa and Masaki Tanaka and Kae Kishimoto and Yasushi Matsuki and Mirei Murakami and Tomoko Ichisaka and Hiroko Murakami and Eijiro Watanabe and Toshiyuki Takagi and Megumi Akiyoshi and Tsuguteru Ohtsubo and Shinji Kihara and Shizuya Yamashita and Makoto Makishima and Tohru Funahashi and Shinya Yamanaka and Ryuji Hiramatsu and Yuji Matsuzawa and Iichiro Shimomura},
  journal={Science},
  year={2005},
  volume={307},
  pages={426 - 430}
}
Fat tissue produces a variety of secreted proteins (adipocytokines) with important roles in metabolism. We isolated a newly identified adipocytokine, visfatin, that is highly enriched in the visceral fat of both humans and mice and whose expression level in plasma increases during the development of obesity. Visfatin corresponds to a protein identified previously as pre–B cell colony-enhancing factor (PBEF), a 52-kilodalton cytokine expressed in lymphocytes. Visfatin exerted insulin-mimetic… Expand
Visfatin--a review.
TLDR
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TLDR
Evidence is provided that visfatin exhibits important autocrine effects on sensitivity of liver cells to insulin action possibly through its effects on NAD biosynthesis. Expand
Visfatin as a novel adipokine in relation to AMP-activated protein kinase in obesity and weight loss
TLDR
The lowered visfatin expression and elevated AMPK activity in visceral adipose tissue in DIO-restricted rats may stimulate fatty acid oxidation, and it is hypothesised that inactive visFatin and activate AMPK may be of therapeutic targets in obesity. Expand
Relation between visfatin as a novel adipokine and AMP-activated protein kinase in obesity
TLDR
The results indicate that the elevated visfatin expression and lowered AMPK activity in visceral adipose tissue in the DIO rats may be related to the development of obese condition in rats. Expand
Reduced plasma visfatin/pre-B cell colony-enhancing factor in obesity is not related to insulin resistance in humans.
TLDR
Visfatin is not related to insulin resistance either as assessed by homeostasis model assessment or during lipid infusion, whereas visfatin mRNA is differentially regulated in SAT and VAT. Expand
Adipokines and etiopathology of metabolic disorders.
White adipose tissue is an endocrine organ producing numerous proteins known as adipokines, which include leptin, adiponectin, resistin, visfatin, and other factors, which are involved in mostExpand
Plasma visfatin concentrations and fat depot-specific mRNA expression in humans.
TLDR
Visceral and subcutaneous adipose tissue display important metabolic differences that underlie the association of visceral obesity with obesity-related cardiovascular and metabolic alterations, but correlation with measures of obesity but not with visceral fat mass or waist-to-hip ratio is found. Expand
Effect of PPAR-α and -γ agonist on the expression of visfatin, adiponectin, and TNF-α in visceral fat of OLETF rats☆
A variety of adipocytokines and peptides secreted from adipocytes have been considered to play a crucial role in obesity, insulin resistance, and type 2 diabetes. Recently, visfatin, a newExpand
Hormonal regulation of the novel adipocytokine visfatin in 3T3-L1 adipocytes.
TLDR
Results show a differential regulation of visfatin mRNA by insulin resistance-inducing hormones, supporting the view that this adipo-cytokine might be an interesting novel candidate linking core components of the metabolic syndrome such as obesity and insulin resistance. Expand
The adipokine visfatin induces tissue factor expression in human coronary artery endothelial cells: another piece in the adipokines puzzle.
TLDR
Data of the present study indicate that visfatin, at doses measurable in ACS patient plasma, induces a procoagulant phenotype in human coronary endothelial cells by promoting TF expression, which supports the hypothesis that this adipokine might play a relevant role as an active partaker in athero-thrombotic disease. Expand
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