Visfatin/pre-B-cell colony-enhancing factor: A protein with various suggested functions

@article{Pilz2007VisfatinpreBcellCF,
  title={Visfatin/pre-B-cell colony-enhancing factor: A protein with various suggested functions},
  author={Stefan Pilz and Harald Mangge and Barbara Obermayer-Pietsch and Winfried M{\"a}rz},
  journal={Journal of Endocrinological Investigation},
  year={2007},
  volume={30},
  pages={138-144}
}
Pre-B-cell colony-enhancing factor (PBEF) was recently found in high levels in visceral fat, and was therefore renamed visfatin. This new adipocytokine exerts insulin-mimetic effects in mice and in cultured cells by binding to and activating the insulin receptor. Despite some recent studies on this topic, the proposed role of visfatin in metabolism remains largely unknown. Initially, PBEF/visfatin was discovered as a cytokine for the differentiation of B-cells. Pre-B-cell colony-enhancing… Expand
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TLDR
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Nicotinamide Phosphoribosyl Transferase/Pre-B Cell Colony-Enhancing Factor/Visfatin Is Required for Lymphocyte Development and Cellular Resistance to Genotoxic Stress1
TLDR
It is unequivocally demonstrated that the ability of the Nampt to regulate cell viability during genotoxic stress requires its enzymatic activity, and it may confer to cells of the immune system the ability to survive during stressful situations such as inflammation. Expand
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TLDR
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TLDR
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Regulation of Inflammatory Cytokine Expression in Pulmonary Epithelial Cells by Pre-B-cell Colony-enhancing Factor via a Nonenzymatic and AP-1-dependent Mechanism*
TLDR
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PBEF promotes the apoptosis of pulmonary microvascular endothelial cells and regulates the expression of inflammatory factors and AQP1 through the MAPK pathways.
TLDR
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TLDR
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Blockade of visfatin induction by oleanolic acid via disturbing IL-6-TRAF6-NF-κB signaling of adipocytes
TLDR
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Early changes in serum visfatin after abdominal surgery: a new pro-inflammatory marker in diagnosis?
TLDR
Serum levels of visfatin detected in the early period after abdominal surgery preceded increase in the levels of other proinflammatory markers including TNF α, IL-6, and CRP, which could serve as an early predictor of the development of inflammatory changes in patients undergoing surgery, particularly those with obesity. Expand
Visfatin level in patients with colorectal adenoma
TLDR
Visfatin serum level does not significantly increase in patients with colorectal adenoma and Site of adenomas within the colon or rectum does not seem to play an important role in this regard as well. Expand
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TLDR
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TLDR
A newly identified adipocytokine, visfatin, that is highly enriched in the visceral fat of both humans and mice and whose expression level in plasma increases during the development of obesity is isolated. Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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