Viscum album aqueous extract induces NOS-2 and NOS-3 overexpression in Guinea pig hearts.

@article{TenorioLpez2006ViscumAA,
  title={Viscum album aqueous extract induces NOS-2 and NOS-3 overexpression in Guinea pig hearts.},
  author={Ferm{\'i}n Alejandro Tenorio-L{\'o}pez and Leonardo Del Valle Mondragon and Gabriela Zarco Olvera and Juan Carlos Torres Narv{\'a}ez and Gustavo Pastel{\'i}n},
  journal={Natural product research},
  year={2006},
  volume={20 13},
  pages={1176-82}
}
Viscum album L. aqueous extract, on the Langendorff isolated and perfused heart model, decreases coronary vascular resistance, when compared to control group (36.00 +/- 2.00 vs. 15.80 +/- 1.96 dyn s cm-5). Our data support the fact that this mechanism involves NOS-2 and NOS-3 overexpression (4.65 and 7.89 times over control, respectively), which is correlated with increases in NO (6.24 +/- 2.49 vs. 147.95 +/- 2.79 pmol) and cGMP production (43.94 +/- 2.00 vs. 74.81 +/- 1.96 pmol mg-1 of tissue… CONTINUE READING

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