Viscosupplementation for Osteoarthritis of the Knee
@article{Rutjes2012ViscosupplementationFO, title={Viscosupplementation for Osteoarthritis of the Knee}, author={Anne W.S. Rutjes and Peter J{\"u}ni and Bruno R. da Costa and Sven Trelle and Eveline N{\"u}esch and Stephan Reichenbach}, journal={Annals of Internal Medicine}, year={2012}, volume={157}, pages={180 - 191} }
BACKGROUND
Viscosupplementation, the intra-articular injection of hyaluronic acid, is widely used for symptomatic knee osteoarthritis. [] Key MethodDATA SOURCES
MEDLINE (1966 to January 2012), EMBASE (1980 to January 2012), the Cochrane Central Register of Controlled Trials (1970 to January 2012), and other sources.
STUDY SELECTION
Randomized trials in any language that compared viscosupplementation with sham or nonintervention control in adults with knee osteoarthritis.
560 Citations
Viscosupplementation for Osteoarthritis of the Knee: A Systematic Review of the Evidence.
- MedicineThe Journal of bone and joint surgery. American volume
- 2015
The most consistent finding was that double-blinded, sham-controlled trials had much smaller treatment effects than trials that were not sufficiently blinded (p < 0.05), and the overall effect was greater but was biased toward stronger treatment effects because of the influence of nonblinded or improperly blinded trials.
A Search for Factors that Predict the Efficacy of Viscosupplementation in Knee Osteoarthritis
- Medicine
- 2014
Factors that predict clinical response to a single intra-articular injection of Hylan GF-20 did not confirm previous predictors of response to hyaluronate injections, and the need for prospective studies to answer this question was highlighted.
Hyaluronic acid injection therapy for osteoarthritis of the knee: concordant efficacy and conflicting serious adverse events in two systematic reviews
- MedicineSystematic Reviews
- 2016
Trials show a small but significant effect of HA on function on which recent systematic reviews agree, but lack of AE synthesis standardization leads to opposite conclusions about the balance of benefits and harms.
Intra-articular hyaluronic acid and corticosteroids in the treatment of knee osteoarthritis: A meta-analysis
- MedicineExperimental and therapeutic medicine
- 2015
A meta-analysis highlights a therapeutic trajectory for intra-articular HA in knee OA pain, as compared with CS, over six months post-intervention; however, in the long term, HA was found to have an enhanced effect.
Viscosupplementation for knee osteoarthritis: systematic review and meta-analysis
- MedicineBMJ
- 2022
Strong conclusive evidence indicates that viscosupplementation leads to a small reduction in knee osteoarthritis pain compared with placebo, but the difference is less than the minimal clinically important between group difference.
Viscosupplementation for treating knee osteoarthrosis: review of the literature☆
- MedicineRevista brasileira de ortopedia
- 2015
Relative efficacy of hyaluronic acid in comparison with NSAIDs for knee osteoarthritis: a systematic review and meta-analysis.
- MedicineSeminars in arthritis and rheumatism
- 2014
Viscosupplementation for Osteoarthritis: a Primer for Primary Care Physicians
- MedicineAdvances in Therapy
- 2013
Evidence suggests that HAs may have value as a first-line therapy in the treatment of knee OA as they have been shown to be more effective in earlier stages and grades of disease, more recently diagnosed OA, and in less severe radiographic OA.
Efficacy and safety of intraarticular hyaluronic acid and corticosteroid for knee osteoarthritis: A meta-analysis.
- MedicineInternational journal of surgery
- 2017
Outcomes of hyaluronic acid injections for glenohumeral osteoarthritis: a systematic review and meta-analysis.
- MedicineJournal of shoulder and elbow surgery
- 2019
References
SHOWING 1-10 OF 182 REFERENCES
Hyaluronic acid injections relieve knee pain.
- MedicineThe Journal of family practice
- 2005
Intra-articular viscosupplementation was moderately effective in relieving knee pain in patients with osteoarthritis at 5 to 7 and 8 to 10 weeks after the last injection but not at 15 to 22 weeks.
Viscosupplementation for the treatment of osteoarthritis of the knee.
- MedicineThe Cochrane database of systematic reviews
- 2005
The pooled analyses of the effects of viscosupplementation against 'placebo' controls generally supported the efficacy of this class of intervention and readers should be cautious, therefore, in drawing conclusions regarding the relative value of different products.
Hylan versus hyaluronic acid for osteoarthritis of the knee: a systematic review and meta-analysis.
- MedicineArthritis and rheumatism
- 2007
Given the likely lack of a superior effectiveness of hylan over hyaluronic acids and the increased risk of local adverse events associated with hylan, the use of intraarticular hylan in patients with knee osteoarthritis in clinical research or practice is discouraged.
Therapeutic trajectory following intra-articular hyaluronic acid injection in knee osteoarthritis--meta-analysis.
- MedicineOsteoarthritis and cartilage
- 2011
Intra-articular hyaluronic acid for the treatment of osteoarthritis of the knee: systematic review and meta-analysis
- MedicineCanadian Medical Association Journal
- 2005
Background: Osteoarthritis of the knee affects up to 10% of the elderly population. The condition is frequently treated by intra-articular injection of hyaluronic acid. We performed a systematic…
Intra-articular hyaluronic acid in treatment of knee osteoarthritis: a meta-analysis.
- MedicineJAMA
- 2003
It is suggested that the highest-molecular-weight hyaluronic acid may be more efficacious in treating knee OA, but heterogeneity of these studies limits definitive conclusions.
Arthroscopic evaluation of potential structure modifying activity of hyaluronan (Hyalgan) in osteoarthritis of the knee.
- MedicineOsteoarthritis and cartilage
- 1997
The effect of viscosupplementation on neuromuscular control of the knee in patients with osteoarthritis.
- MedicineJournal of back and musculoskeletal rehabilitation
- 2009
It was demonstrated that intraarticular injection of hyaluronan in patients with knee OA led to a short-term increase in proprioception and isokinetic muscle force, and also significant improvements in the functional conditions of patients.
Intra-articular hyaluronan injections for the treatment of osteoarthritis of the knee: a randomized, double blind, placebo controlled study.
- MedicineClinical and experimental rheumatology
- 2001
The results through week 20 indicate that BioHy provides relief for osteoarthritic patients without causing adverse effects, although the study was not sufficiently powered to obtain statistically significant differences between the treatment groups.