Viscoelasticity of amyloid plaques in transgenic mouse brain studied by Brillouin microspectroscopy and correlative Raman analysis.

@article{Mattana2017ViscoelasticityOA,
  title={Viscoelasticity of amyloid plaques in transgenic mouse brain studied by Brillouin microspectroscopy and correlative Raman analysis.},
  author={Sara Mattana and Silvia Caponi and Francesco Tamagnini and Daniele Fioretto and Francesca Palombo},
  journal={Journal of innovative optical health sciences},
  year={2017},
  volume={10 6}
}
Amyloidopathy is one of the most prominent hallmarks of Alzheimer's disease (AD), the leading cause of dementia worldwide, and is characterized by the accumulation of amyloid plaques in the brain parenchyma. The plaques consist of abnormal deposits mainly composed of an aggregation-prone protein fragment, β-amyloid 1-40/1-42, into the extracellular matrix. Brillouin microspectroscopy is an all-optical contactless technique that is based on the interaction between visible light and longitudinal… CONTINUE READING
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