Viscoelasticity of Staphylococcus aureus biofilms in response to fluid shear allows resistance to detachment and facilitates rolling migration.

@article{Rupp2005ViscoelasticityOS,
  title={Viscoelasticity of Staphylococcus aureus biofilms in response to fluid shear allows resistance to detachment and facilitates rolling migration.},
  author={Cory J. Rupp and Christoph A Fux and Paul Stoodley},
  journal={Applied and environmental microbiology},
  year={2005},
  volume={71 4},
  pages={2175-8}
}
Staphylococcus aureus is a leading cause of catheter-related bloodstream infections and endocarditis. Both involve (i) biofilm formation, (ii) exposure to fluid shear, and (iii) high rates of dissemination. We found that viscoelasticity allowed S. aureus biofilms to resist detachment due to increased fluid shear by deformation, while remaining attached to a surface. Further, we report that S. aureus microcolonies moved downstream by rolling along the lumen walls of a glass flow cell, driven by… CONTINUE READING

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