Viscoelastic measurements of single molecules on a millisecond time scale by magnetically driven oscillation of an atomic force microscope cantilever.

@article{Kawakami2005ViscoelasticMO,
  title={Viscoelastic measurements of single molecules on a millisecond time scale by magnetically driven oscillation of an atomic force microscope cantilever.},
  author={Masaru Kawakami and Katherine M Byrne and Bhavin S Khatri and Tom McLeish and Sheena E Radford and D Alastair M Smith},
  journal={Langmuir : the ACS journal of surfaces and colloids},
  year={2005},
  volume={21 10},
  pages={4765-72}
}
The dynamical nature of biomolecular systems means that knowledge of their viscoelastic behavior is important in fully understanding function. The linear viscoelastic response can be derived from an analysis of Brownian motion. However, this is a slow measurement and technically demanding for many molecular systems of interest. To address this issue, we have developed a simple method for measuring the full linear viscoelastic response of single molecules based on magnetically driven… CONTINUE READING
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