Visceral neuropathy and intestinal pseudo-obstruction in a murine model of a nuclear inclusion disease.

@article{Clarke2007VisceralNA,
  title={Visceral neuropathy and intestinal pseudo-obstruction in a murine model of a nuclear inclusion disease.},
  author={Christine M Clarke and Cara Plata and Bonnie L Cole and Karen Tsuchiya and Albert R La Spada and Raj P Kapur},
  journal={Gastroenterology},
  year={2007},
  volume={133 6},
  pages={1971-8}
}
BACKGROUND & AIMS Intestinal dysmotility is a component of many neurodegenerative disorders, including some characterized by neuronal intranuclear inclusions. PrP-SCA7-92Q transgenic mice phenocopy many aspects of the human polyglutamine neurodegenerative disorder spinocerebellar ataxia type 7 (SCA7). The enteric neuropathology of PrP-SCA7-92Q mice was investigated after observing that they develop signs of intestinal pseudo-obstruction. METHODS Gastrointestinal transit of radio-opaque… CONTINUE READING

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