Visceral analgesic effect of 5-HT4 receptor agonist in rats involves the rostroventral medulla (RVM)

@article{Sengupta2014VisceralAE,
  title={Visceral analgesic effect of 5-HT4 receptor agonist in rats involves the rostroventral medulla (RVM)},
  author={Jyoti N. Sengupta and Aaron Mickle and Pradeep Kannampalli and Russell Spruell and Adri{\'a}n Gerardo Carmona Miranda},
  journal={Neuropharmacology},
  year={2014},
  volume={79},
  pages={345-358}
}
The 5-HT(4) receptor agonist tegaserod (TEG) has been reported to modulate visceral pain. However, the underlying mechanism remains unknown. The objective of the present study was to examine the analgesic mechanism and site of action of TEG. In male rats, visceral pain was assessed by measuring visceromotor response (VMR) to colorectal distension (CRD). Inflammation was induced by intracolonic injection of tri-nitrobenzene sulfonic acid (TNBS). The effect of TEG on the VMR was tested by… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-8 OF 8 CITATIONS

Role of Principal Ionotropic and Metabotropic Receptors in Visceral Pain

  • Journal of neurogastroenterology and motility
  • 2015
VIEW 1 EXCERPT
CITES BACKGROUND