Visceral adipose tissue-derived serine proteinase inhibitor inhibits apoptosis of endothelial cells as a ligand for the cell-surface GRP78/voltage-dependent anion channel complex.

@article{Nakatsuka2013VisceralAT,
  title={Visceral adipose tissue-derived serine proteinase inhibitor inhibits apoptosis of endothelial cells as a ligand for the cell-surface GRP78/voltage-dependent anion channel complex.},
  author={Atsuko Nakatsuka and Jun Wada and Izumi Iseda and Sanae Teshigawara and Kanji Higashio and Kazutoshi Murakami and Motoko Kanzaki and Kentaro Inoue and Takahiro Terami and Akihiro Katayama and Kazuyuki Hida and Jun Eguchi and Daisuke Ogawa and Yasushi Matsuki and Ryuji Hiramatsu and H. Yagita and Shigeru Kakuta and Yoichiro Iwakura and Hirofumi Makino},
  journal={Circulation research},
  year={2013},
  volume={112 5},
  pages={771-80}
}
RATIONALE Visceral adipose tissue-derived serine proteinase inhibitor (vaspin) is an adipokine identified from visceral adipose tissues of genetically obese rats. OBJECTIVE The role of vaspin in the diabetic vascular complications remains elusive, and we investigated the effects of vaspin on the vascular function under the diabetic milieu. METHODS AND RESULTS Adenovirus carrying the full length of the vaspin gene (Vaspin-Ad) ameliorated intimal proliferation of balloon-injured carotid… CONTINUE READING
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