Viruses and the TNF-related cytokines, an evolving battle.

  title={Viruses and the TNF-related cytokines, an evolving battle.},
  author={Chris A Benedict},
  journal={Cytokine & growth factor reviews},
  volume={14 3-4},
Tumor necrosis factor (TNF)-related cytokines are critical effector molecules in the immune response to viral pathogens. Engagement of the TNF receptors by their cognate ligands activates apoptotic and non-apoptotic signaling pathways, both of which can mediate antiviral activity. In response, viruses have evolved mechanisms to inhibit signaling by some cytokines of the TNF superfamily. These strategies are largely unique to each class of virus, but are similar in that they all target key… CONTINUE READING

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