Viruses and bacteria in acute asthma exacerbations--a GA² LEN-DARE systematic review.

  title={Viruses and bacteria in acute asthma exacerbations--a GA² LEN-DARE systematic review.},
  author={Nikolaos G. Papadopoulos and Ioannis S Christodoulou and Gernot G U Rohde and Ioana Agache and Catarina Almqvist and Andreina Bruno and Sergio Bonini and Louis J. Bont and Apostolos Bossios and Jean Bousquet and Fulvio Braido and Guy Brusselle and Giorgio Walter Canonica and K. H. Carlsen and Pascal Chanez and Wytske Johanna Fokkens and Marcos Garc{\'i}a-Garc{\'i}a and Mark Gjomarkaj and Tari Haahtela and Stephen T. Holgate and S. L. Johnston and G. Konstantinou and M. Kowalski and Anna Lewandowska-Polak and Karin C L\odrup-Carlsen and Mika M{\"a}kel{\"a} and Ivana Malkusov{\'a} and Joaquim Mullol and Antonio Nieto and Esben Eller and Cueneyt Ozdemir and Petr Panzner and Todor Popov and Stelios Psarras and Eirini Roumpedaki and M. M. Rukhadze and Asja Stipi{\'c}-Markovi{\'c} and Ana Todo Bom and Elina M Toskala and Paul van Cauwenberge and Cornelis Maria van Drunen and J B Watelet and Maria Xatzipsalti and Paraskevi Xepapadaki and Torsten Zuberbier},
  volume={66 4},
A major part of the burden of asthma is caused by acute exacerbations. Exacerbations have been strongly and consistently associated with respiratory infections. Respiratory viruses and bacteria are therefore possible treatment targets. To have a reasonable estimate of the burden of disease induced by such infectious agents on asthmatic patients, it is necessary to understand their nature and be able to identify them in clinical samples by employing accurate and sensitive methodologies. This… CONTINUE READING
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