Virus spread and immune response following anterior chamber inoculation of HSV-1 Lacking the Beclin-binding domain (BBD)

@article{Zhang2013VirusSA,
  title={Virus spread and immune response following anterior chamber inoculation of HSV-1 Lacking the Beclin-binding domain (BBD)},
  author={Ming Zhang and Jason J Covar and Nancy Y Zhang and W Chen and Sally S. Atherton},
  journal={Journal of Neuroimmunology},
  year={2013},
  volume={260},
  pages={82-91}
}
The autophagy response induced by HSV-1 infection is antagonized by the Beclin-binding domain (BBD). The purpose of this study was to determine if lack of the BBD affects viral spread and immune response in the eyes and brain. Our results showed that lack of the BBD increases autophagy response and activation of NLRP3 inflammasome, which in turn induces a more rapid innate immune response mediated by macrophage/microglia and NK cells in the injected eye, limiting virus replication and retinal… CONTINUE READING

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