Virus-like particles as carriers for T-cell epitopes: limited inhibition of T-cell priming by carrier-specific antibodies.

@article{Ruedl2005ViruslikePA,
  title={Virus-like particles as carriers for T-cell epitopes: limited inhibition of T-cell priming by carrier-specific antibodies.},
  author={Christiane Ruedl and Katrin Schwarz and Andrea Jegerlehner and Tazio Storni and Vania Manolova and Martin F Bachmann},
  journal={Journal of virology},
  year={2005},
  volume={79 2},
  pages={
          717-24
        }
}
Virus-like particles (VLPs) are able to induce cytotoxic T-cell responses in the absence of infection or replication. This makes VLPs promising candidates for the development of recombinant vaccines. However, VLPs are also potent inducers of B-cell responses, and it is generally assumed that such VLP-specific antibodies interfere with the induction of protective immune responses, a phenomenon summarized as carrier suppression. In this study, we investigated the impact of preexisting VLP… CONTINUE READING

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Effect of preexisting neutralizing antibodies on the anti-tumor immune response induced by chimeric human papillomavirus virus-like particle vaccines

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