Virus-like interference in the latency and prevention of Creutzfeldt-Jakob disease.

  title={Virus-like interference in the latency and prevention of Creutzfeldt-Jakob disease.},
  author={L. Manuelidis and Zhi Yun Lu},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={100 9},
We previously showed that intracerebral (ic) inoculation of the attenuated SY strain of Creutzfeld-Jakob disease in mice could delay clinical signs and widespread neuropathology evoked by subsequent ic challenge with the more virulent FU strain. Using lower doses of SY and FU ic, we here demonstrate that mice can be protected well into old age without demonstrable neuropathology or pathologic prion protein (PrP-res). In contrast, parallel FU only controls became terminally diseased 1 year… CONTINUE READING
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M Ed Ic a L Sc Ie N Ce S

  • M. Shlomchik, K. Radebold, N. Duclos, L. Manuelidis
  • BMC Infect. Dis
  • 2001

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