Virus-like Peptide Vaccines Against Aß N-terminal or C-Terminal Domains Reduce Amyloid Deposition in APP Transgenic Mice without Addition of Adjuvant

Abstract

Immunotherapy against the Aß peptide is increasingly viewed as an effective means of preventing and even decreasing Aß deposition in transgenic mouse models and human cases of Alzheimer's disease. A prior active immunization trial was halted due to adverse events which occurred subsequent to a change in the adjuvant used in the vaccine preparation. Although… (More)
DOI: 10.1007/s11481-009-9183-1

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