Virus interference. I. The interferon

  title={Virus interference. I. The interferon},
  author={Alick Isaacs and Jean Lindenmann},
  journal={Proceedings of the Royal Society of London. Series B - Biological Sciences},
  pages={258 - 267}
  • A. Isaacs, J. Lindenmann
  • Published 12 September 1957
  • Biology
  • Proceedings of the Royal Society of London. Series B - Biological Sciences
During a study of the interference produced by heat-inactivated influenza virus with the growth of live virus in fragments of chick chorio-allantoic membrane it was found that following incubation of heated virus with membrane a new factor was released. This factor, recognized by its ability to induce interference in fresh pieces of chorio-allantoic membrane, was called interferon. Following a lag phase interferon was first detected in the membranes after 3 h incubation and thereafter it was… Expand
Virus interference. I. The interferon.
  • A. Isaacs, J. Lindenmann
  • Biology, Medicine
  • Proceedings of the Royal Society of London. Series B, Biological sciences
  • 1957
Interferon induction by influenza type C.
The presence of a heat-stable interferon-like inhibitor in allantoic and amniotic fluids collected from chick embryos infected with type C influenza virus was determined. This inhibitor wasExpand
Interferon Action: Control of RNA Processing, Translation and Degradation
“During a study of the interference produced by heat-inactivated influenza virus with the growth of live virus in fragments of chick chorioallantoic membrane it was found that following incubation ofExpand
Interferons: Selectivity and Specificity of Action in Cell-Free Systems
Calf, mouse, and chicken interferons inhibited these enzymes with the same characteristic species specificity observed in tissue culture, and a mechanism of action is proposed. Expand
The multiplication of influenza virus. III. Heterologous interference.
Heterologous interference established by ultraviolet-irradiated virus has been investigated and it is shown that large doses of interfering agent establish a solid interference which cannot be overcome, regardless of the size of the challenge dose administered. Expand
Research on Interferon: A Review 1
  • D. Tyrrell
  • Medicine
  • Journal of the Royal Society of Medicine
  • 1981
Because the amounts of interferon produced steadily increased, it was eventually possible to do trials showing that typical virus infections of man could be prevented or treated, and so the Scientific Committee on Interferon was set up, with participants from the Medical Research Council and three pharmaceutical research laboratories. Expand
This communication attempts to review some of the salient features of this antiviral product, capable of protecting susceptible cells against viral infection even in the absence of interfering virus. Expand
Production of interferon by chick embryo cells exposed to Rous sarcoma virus.
An interferon-like inhibitor has been demonstrated in cultures of chick embryo cells exposed to active or heat-inactivated Rous sarcoma virus (RSV) and it is concluded that a single unit of interferons is sufficient to inhibit the consequences of infection caused by a single infectious particle of RSV. Expand
Interferon induction in man by a synthetic polyanion of defined composition.
Although human interferon can be produced in tissue culture and appears during a variety of Naturally occurring and artificially induced virus infections in man – both in serum and in infected tissue – it has not been obtained in quantities sufficient for treatment of naturally occurring virus infections. Expand
Exogenous interferon in animals and its clinical implications.
  • N. Finter
  • Medicine
  • Archives of internal medicine
  • 1970
Interferons are made by cells infected with a virus or exposed to certain other stimuli, and they have the important property of making other cells resistant to virus infection. Expand


Developmental cycles in animal viruses.
  • W. Henle
  • Biology, Medicine
  • Cold Spring Harbor symposia on quantitative biology
  • 1953