Virus-induced over-expression of protein phosphatase 2A inhibits insulin signalling in chronic hepatitis C.

  title={Virus-induced over-expression of protein phosphatase 2A inhibits insulin signalling in chronic hepatitis C.},
  author={Christine Bernsmeier and François H. T. Duong and Verena Christen and Paolo Pugnale and F. de Toro Negro and Luigi Maria Terracciano and Markus H Heim},
  journal={Journal of hepatology},
  volume={49 3},
BACKGROUND/AIMS Hepatitis C virus (HCV) infection disturbs glucose and lipid metabolism contributing to the development of liver steatosis, insulin resistance and type 2 diabetes mellitus. On the other hand, insulin resistance and steatosis have been found to be associated with increased rates of fibrosis progression and lower rates of response to interferon therapy in chronic hepatitis C (CHC). The molecular mechanisms contributing to insulin resistance in CHC are not well understood. We have… CONTINUE READING
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