Virus-induced diabetes mellitus. XV. Beta cell damage and insulin- dependent hyperglycemia in mice infected with coxsackie virus B4

@article{Yoon1978VirusinducedDM,
  title={Virus-induced diabetes mellitus. XV. Beta cell damage and insulin- dependent hyperglycemia in mice infected with coxsackie virus B4},
  author={J. W. Yoon and Takashi Onodera and Abner Louis Notkins},
  journal={The Journal of Experimental Medicine},
  year={1978},
  volume={148},
  pages={1068 - 1080}
}
Coxsackie virus B4 that had been passaged in cultures enriched for pancreatic beta cells produced a diabetes-like syndrome when inoculated into SJL/J mice. The infection resulted in insulitis and destruction of beta cells. Viral antigens were found in beta cells by staining with fluorescein-labeled antibody to Coxsackie virus B4. The destruction of beta cells led to a decrease in the immunoreactive insulin content of the pancreas and hypoinsulinemia. The reduction in immunoreactive insulin… CONTINUE READING
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A Coxsackie virus B3 variant cytopathic for pancreatic beta cells

  • T. A. Stoneback, R. L. Crowell
  • Annual Meeting, Am. Soc. Microbiol. (Abstract)
  • 1977
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