Virus-induced decrease of insulin receptors in cultured human cells.

  title={Virus-induced decrease of insulin receptors in cultured human cells.},
  author={Fujio Shimizu and John J. Hooks and C Ronald Kahn and Abner Louis Notkins},
  journal={The Journal of clinical investigation},
  volume={66 5},
Viral infections may produce abnormalities in carbohydrate metabolism in normal subjects and profound changes in glucose homeostasis in insulin-dependent diabetics. Using an in vitro radio-receptor assay with 125I-labeled insulin and human-amnion (WISH) cells, the effect of viral infections on insulin receptors was examined. Both herpes simplex virus and vesicular stomatitis virus produced a 50% decrease in insulin binding. There was no evidence that this decrease was due to degradation of… CONTINUE READING