Virus-host interactions in hepatitis C virus infection: implications for molecular pathogenesis and antiviral strategies.

@article{Georgel2010VirushostII,
  title={Virus-host interactions in hepatitis C virus infection: implications for molecular pathogenesis and antiviral strategies.},
  author={Philippe Georgel and Catherine Schuster and Mirjam B. Zeisel and Françoise Stoll-Keller and Thomas Berg and Seiamak Bahram and Thomas F Baumert},
  journal={Trends in molecular medicine},
  year={2010},
  volume={16 6},
  pages={277-86}
}
With a global burden of 170 million chronically infected patients and a major cause of liver cirrhosis and hepatocellular carcinoma, hepatitis C virus (HCV) is a major public health challenge. Recent discoveries of viral and cellular factors mediating virus-host interactions have allowed scientists to uncover the key molecular mechanisms of viral infection and escape from innate and adaptive immune responses. These include the discovery of tight junction proteins as entry factors and microRNA… CONTINUE READING