Virus-derived DNA drives mosquito vector tolerance to arboviral infection

  title={Virus-derived DNA drives mosquito vector tolerance to arboviral infection},
  author={Bertsy Goic and Kenneth A. Stapleford and Lionel Frangeul and Aur{\'e}lien J Doucet and Val{\'e}rie Gausson and Herv{\'e} Blanc and Nidia Schemmel-Jofre and Gael Cristofari and Louis Lambrechts and Marco Vignuzzi and Maria-Carla Saleh},
  booktitle={Nature communications},
Mosquitoes develop long-lasting viral infections without substantial deleterious effects, despite high viral loads. This makes mosquitoes efficient vectors for emerging viral diseases with enormous burden on public health. How mosquitoes resist and/or tolerate these viruses is poorly understood. Here we show that two species of Aedes mosquitoes infected with two arboviruses from distinct families (dengue or chikungunya) generate a viral-derived DNA (vDNA) that is essential for mosquito survival… CONTINUE READING
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