Virus burden in long-term survivors of human immunodeficiency virus (HIV) infection is a determinant of anti-HIV CD8+ lymphocyte activity.

@article{Ferbas1995VirusBI,
  title={Virus burden in long-term survivors of human immunodeficiency virus (HIV) infection is a determinant of anti-HIV CD8+ lymphocyte activity.},
  author={John Ferbas and Andrew H. Kaplan and Mary Ann Hausner and Lance E. Hultin and Jose L Matud and Zhensheng Liu and Dennis L. Panicali and H Nerng-Ho and Roger Detels and Janis V. Giorgi},
  journal={The Journal of infectious diseases},
  year={1995},
  volume={172 2},
  pages={
          329-39
        }
}
Persons infected with human immunodeficiency virus (HIV) for > 8 years were studied to delineate virologic and immunologic attributes of long-term survival. Whereas those with 300-700 CD4+ cells/microL often had circulating cytotoxic T lymphocytes (CTL) against HIV antigens, those with > 1000 CD4+ cells/microL did not. The subjects with > 1000 CD4+ cells/microL had low virus burden, low levels of Gag-specific CTL precursors, and minimal CD8+ cell activation. Overall, elevated levels of CD8… CONTINUE READING
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