Virus budding and the ESCRT pathway.

  title={Virus budding and the ESCRT pathway.},
  author={J{\"o}rg Votteler and Wesley I. Sundquist},
  journal={Cell host & microbe},
  volume={14 3},
Enveloped viruses escape infected cells by budding through limiting membranes. In the decade since the discovery that HIV recruits cellular ESCRT (endosomal sorting complexes required for transport) machinery to facilitate viral budding, this pathway has emerged as the major escape route for enveloped viruses. In cells, the ESCRT pathway catalyzes analogous membrane fission events required for the abscission stage of cytokinesis and for a series of "reverse topology" vesiculation events… CONTINUE READING
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