Virus-associated hemophagocytic syndrome: a benign histiocytic proliferation distinct from malignant histiocytosis.

@article{Risdall1979VirusassociatedHS,
  title={Virus-associated hemophagocytic syndrome: a benign histiocytic proliferation distinct from malignant histiocytosis.},
  author={R J Risdall and Robert W Mckenna and Mark E. Nesbit and William Krivit and Henry H. Balfour and Richard L. Simmons and Richard D. Brunning},
  journal={Cancer},
  year={1979},
  volume={44 3},
  pages={993-1002}
}
Nineteen patients whose bone marrow smears showed histiocytic hyperplasia with prominent hemophagocytosis were found to have a clinicopathologic syndrome associated with active viral infection. High fever, constitutional symptoms, liver function, and coagulation abnormalities and peripheral blood cytopenias were characteristic findings. Hepatosplenomegaly, lymphadenopathy, bilateral pulmonary infiltrates, and skin rash were often present. Fourteen of the patients were immunosuppressed. Active… CONTINUE READING
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