Virus and cell fusion mechanisms.

  title={Virus and cell fusion mechanisms.},
  author={Benjamin Podbilewicz},
  journal={Annual review of cell and developmental biology},
In biomembrane fusion pathways, membranes are destabilized through insertions of amphipathic protein segments, lipid reorganization via hemifusion, protein restructuring, and dimpling of the membranes. Four classes of membrane proteins are known in virus and cell fusion. Class I virus-cell fusion proteins (fusogens) are α-helix-rich prefusion trimers that form coiled-coil structures that insert hydrophobic fusion peptides or loops (FPs or FLs) into membranes and refold into postfusion trimers… CONTINUE READING