Virus- and cell-encoded tyrosine protein kinases inactivate DNA topoisomerases in vitro.

Abstract

Tyrosine protein kinase activity is associated with at least eight different retrovirus-encoded onc gene products and with cell receptors for epidermal growth factor, platelet-derived growth factor, tumour growth factor and insulin. Both the onc kinases and the growth factor receptors are membrane proteins whose enzymatic activity has been implicated in… (More)

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