Virus Neutralisation: New Insights from Kinetic Neutralisation Curves

@inproceedings{Magnus2013VirusNN,
  title={Virus Neutralisation: New Insights from Kinetic Neutralisation Curves},
  author={Carsten Magnus},
  booktitle={PLoS Computational Biology},
  year={2013}
}
Antibodies binding to the surface of virions can lead to virus neutralisation. Different theories have been proposed to determine the number of antibodies that must bind to a virion for neutralisation. Early models are based on chemical binding kinetics. Applying these models lead to very low estimates of the number of antibodies needed for neutralisation. In contrast, according to the more conceptual approach of stoichiometries in virology a much higher number of antibodies is required for… CONTINUE READING