Virus-Infection or 5′ppp-RNA Activates Antiviral Signal through Redistribution of IPS-1 Mediated by MFN1

@inproceedings{Onoguchi2010VirusInfectionO5,
  title={Virus-Infection or 5′ppp-RNA Activates Antiviral Signal through Redistribution of IPS-1 Mediated by MFN1},
  author={Kazuhide Onoguchi and Koji Onomoto and Shiori Takamatsu and Michihiko Jogi and Azumi Takemura and Shiho Morimoto and Ilkka Julkunen and Hideo Namiki and M. Yoneyama and Takashi Fujita},
  booktitle={PLoS pathogens},
  year={2010}
}
In virus-infected cells, RIG-I-like receptor (RLR) recognizes cytoplasmic viral RNA and triggers innate immune responses including production of type I and III interferon (IFN) and the subsequent expression of IFN-inducible genes. Interferon-beta promoter stimulator 1 (IPS-1, also known as MAVS, VISA and Cardif) is a downstream molecule of RLR and is expressed on the outer membrane of mitochondria. While it is known that the location of IPS-1 is essential to its function, its underlying… CONTINUE READING

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