Virulent Strain of Hepatitis E Virus Genotype 3, Japan

  title={Virulent Strain of Hepatitis E Virus Genotype 3, Japan},
  author={Kazuaki Takahashi and Hiroaki Okamoto and Natsumi Abe and Manri Kawakami and Hiroyuki Matsuda and Satoshi Mochida and Hiroshi Sakugawa and Yoshiki Suginoshita and Seishiro Watanabe and Kazuhide Yamamoto and Yuzo Miyakawa and Shunji Mishiro},
  journal={Emerging Infectious Diseases},
  pages={704 - 709}
Hepatitis E virus (HEV) genotype 3, which usually causes asymptomatic infection in Japan, induced severe hepatitis in 8 patients. To better understand genetic features of HEV associated with increased virulence, we determined the complete or near-complete nucleotide sequences of HEV from these 8 patients and from 5 swine infected with genotype 3 strain swJ19. Phylogenetic analysis showed that the isolates from the 8 patients and the 5 swine grouped separately from the other genotype 3 isolates… CONTINUE READING


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