Virulence of the zoonotic agent of leptospirosis: still terra incognita?

@article{Picardeau2017VirulenceOT,
  title={Virulence of the zoonotic agent of leptospirosis: still terra incognita?},
  author={Mathieu Picardeau},
  journal={Nature Reviews Microbiology},
  year={2017},
  volume={15},
  pages={297-307}
}
  • M. Picardeau
  • Published 1 May 2017
  • Biology, Medicine
  • Nature Reviews Microbiology
Pathogenic leptospires are the bacterial agents of leptospirosis, which is an emerging zoonotic disease that affects animals and humans worldwide. The success of leptospires as pathogens is explained by their spiral shape and endoflagellar motility (which enable these spirochetes to rapidly cross connective tissues and barriers), as well as by their ability to escape or hijack the host immune system. However, the basic biology and virulence factors of leptospires remain poorly characterized. In… Expand
Heat Shock Proteins in Leptospirosis
TLDR
This chapter summarizes the current knowledge of HSP expression and their roles in leptospirosis and also extensively discusses future perspectives of this arena to battle leptosphereirosis with the ultimate goals for better therapeutic outcome and successful prevention. Expand
Insight into motility-dependent pathogenicity of the zoonotic spirochete Leptospira
TLDR
Adhesivity and crawling motility over host tissue surfaces are closely related to the pathogenicity of a zoonotic spirochete, which associate the kinetics and kinematic features of the spirochetal pathogens with their virulence. Expand
Leptospirosis and Coinfection: Should We Be Concerned?
TLDR
The occurrence of leptospirosis with other diseases should be of concern and may depend on the success of the transmission and severity of individual infections, as well as medical practitioners who misdiagnose the presence of multiple infections. Expand
Leptospira and Leptospirosis.
  • M. Picardeau
  • Medicine, Biology
  • Methods in molecular biology
  • 2020
TLDR
The taxonomy of Leptospira has recently undergone extensive revisions with the use of whole-genome sequences, thus expanding considerably the number of species. Expand
Isolation and phenotypic identification of Leptospires from Rattus norvegicus (Brown rat)
TLDR
The isolation and phenotypic identification of Leptospira in rodent carriers, which are central to the epidemiology of the disease, are demonstrated. Expand
Adhesivity and motility of a zoonotic spirochete: Implications in host-dependent pathogenicity
TLDR
The role of adhesivity and motility of the zoonotic spirochete Leptospira in host-dependent pathogenicity is shown and correlated with the severity of infection in the host. Expand
Infection by Leptospira spp. in Domestic Cats (Felis silvestris catus). A Review
TLDR
It is known that the cat is no longer considered a refractory species for leptospirosis, therefore, its epidemiology and therapeutic approach needs to be better clarified. Expand
Crawling Motility on the Host Tissue Surfaces Is Associated With the Pathogenicity of the Zoonotic Spirochete Leptospira
TLDR
The authors' results associate the kinetics and kinematic features of the spirochetal pathogens with their virulence, and found that, in the case of the pathogenic leptospires, a larger fraction of bacteria attached to the host cells and persistently traveled long distances using the crawling mechanism. Expand
Leptospira Infections in Domestic and Wild Animals
TLDR
The studies published in this Special Issue have evidenced and confirmed the hidden role of a large variety of animal species, domestic and wild, in the leptospirosis epidemiology and highlighted the necessity for continuous monitoring and large-scale surveillance studies to better understand this neglected and re-emerging zoonosis. Expand
Leptospiral Infection, Pathogenesis and Its Diagnosis—A Review
TLDR
The basis of leptospiral infection, including its risk factors, classification, morphology, transmission, pathogenesis, co-infections and clinical manifestations are highlighted in this review and the various diagnostic techniques are outlined with emphasis on their respective pros and cons. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 129 REFERENCES
Leptospira spp.: Novel insights into host-pathogen interactions.
TLDR
This work compiles the main described leptospiral proteins that could act as adhesins, as PLG and fibrinogen receptors and as complement regulator binding proteins. Expand
Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen
TLDR
The life cycle of the bacterium, the recent advances in understanding and the implications for the future prevention of leptospirosis are discussed. Expand
The molecular basis of leptospiral pathogenesis.
  • G. Murray
  • Biology, Medicine
  • Current topics in microbiology and immunology
  • 2015
TLDR
There remains a lack of understanding of how Leptospira causes tissue pathology, and it is likely that leptospires have many novel pathogenesis mechanisms that are yet to be identified. Expand
Leptospirosis: a zoonotic disease of global importance.
TLDR
The completion of the genome sequence of Leptospira interrogans serovar lai, and other continuing leptospiral genome sequencing projects, promise to guide future work on the disease. Expand
LipL32 Is a Subsurface Lipoprotein of Leptospira interrogans: Presentation of New Data and Reevaluation of Previous Studies
TLDR
Evidence for a sub-surface location for most or all of the major leptospiral lipoprotein, LipL32, is presented based on surface immunofluorescence utilizing three different types of antibodies and four different permeabilization methods, as well as surface proteolysis of intact and lysedLeptospires. Expand
Inactivation of clpB in the Pathogen Leptospira interrogans Reduces Virulence and Resistance to Stress Conditions
TLDR
It is demonstrated that ClpB is involved in the general stress response and the chaperone is also necessary, either directly or indirectly, for the virulence of the pathogen L. interrogans. Expand
Leptospira and Bats: Story of an Emerging Friendship
TLDR
It is shown how this system can provide exciting new opportunities to obtain insights into the evolutionary ecology of bat-borne pathogens and propose future directions to disentangle the role of bats in human leptospirosis. Expand
The OmpA-Like Protein Loa22 Is Essential for Leptospiral Virulence
TLDR
Loa22 is necessary for virulence of L. interrogans in the animal model and represents the first genetically defined virulence factor in Leptospira species, according to predicted OmpA domain based on sequence identity. Expand
Biofilm formation by saprophytic and pathogenic leptospires.
TLDR
This study investigated the characteristics of biofilm development by both saprophytic and pathogenic Leptospira species using microscopic examinations and a polystyrene plate model and found cells embedded in an extracellular matrix formed preferentially on glass and poly Styrene surfaces. Expand
Pathogenesis of leptospirosis: the influence of genomics.
TLDR
Interestingly, inactivation of a number of genes hypothesised to encode virulence factors based on in vitro virulence-associated properties did not result in attenuation of virulence, suggesting a degree of functional redundancy in leptospiral pathogenic mechanisms. Expand
...
1
2
3
4
5
...